| 化学反応創成研究室北海道大学

Membersメンバー

TOP
Members
林裕樹

林裕樹

Hiroki Hayashi

特任准教授

TEL: 011-706-9654
FAX: 011-706-9655
E-mail: hhayashi@icredd.hokudai.ac.jp
ROOM: 創成科学研究棟05-116

Trans-Selective Carboxylative Cyclization of 1,6-Dienes Using the CO₂ Radical Anion

Song, Y.; Hayashi, H.; Mangaonkar, S.; Mita, T. Chem. Lett. 2024, 53, in press.

DOI : 10.1093/chemle/upae149
Strain-Releasing Ring-Opening Diphosphinations for the Synthesis of Diphosphine Ligands with Cyclic Backbones

Krishnan, C. G.; Takano, H.; Katsuyama, H.; Kanna, W.; Hayashi, H.; Mita, T. JACS Au 2024, 4, in press.

DOI : 10.1021/jacsau.4c00347
γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO₂ Radical Anion

Mangaonkar, S. R.; Hayashi, H.; Kanna, W.; Debbarma, S.; Harabuchi, Y.; Maeda, S.; Mita, T. Precis. Chem. 2024, 2, 88 - 95.

DOI : 10.1021/prechem.3c00117
Revisiting the Electrochemical Carboxylation of Naphthalene with CO₂: Selective Monocarboxylation of 2-Substituted Naphthalenes

Rawat, V. K.; Hayashi, H.; Katsuyama, H.; Mangaonkar, S. R.; Mita, T. Org. Lett. 2023, 25, 4231 - 4235.

DOI : 10.1021/acs.orglett.3c01033
Quantum Chemical Calculations for Reaction Prediction in the Development of Synthetic Methodologies

Hayashi, H.; Maeda, S.; Mita, T. Chem. Sci. 2023, 14, 11601 - 11616 .

DOI : 10.1039/D3SC03319H
Synthesis of Bicyclo[1.1.1]pentane (BCP)-Based Straight-Shaped Diphosphine Ligands

Takano, H.; Katsuyama, H.; Hayashi, H.; Harukawa, M.; Tsurui, M.; Shoji, S.; Hasegawa, Y.; Maeda, S.; Mita, T. Angew. Chem., Int. Ed. 2023, 62, e202303435.

DOI : 10.1002/anie.202303435
Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO₂ Radical Anion to (Hetero)Aromatics

Mangaonkar, S. R.; Hayashi, H.; Takano, H.; Kanna, W.; Maeda, S.; Mita, T. ACS Catal. 2023, 13, 2482 - 2488.

DOI : 10.1021/acscatal.2c06192
Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction

Harabuchi, Y.; Hayashi, H.; Takano, H.; Mita, T.; Maeda, S. Angew. Chem., Int. Ed. 2023, 62, e202211936.

DOI : 10.1002/anie.202211936
Toward ab initio Reaction Discovery Using the Artificial Force Induced Reaction Method

Maeda, S.; Harabuchi, Y.; Hayashi, H.; Mita, T. Annu. Rev. Phys. Chem. 2023, 74, 287 - 311.

DOI : 10.1146/annurev-physchem-102822-101025
Prediction of High-Yielding Single-Step or Cascade Pericyclic Reactions for the Synthesis of Complex Synthetic Targets

Mita, T.; Takano, H.; Hayashi, H.; Kanna, W.; Harabuchi, Y.; Houk, K. N.; Maeda, S. J. Am. Chem. Soc. 2022, 144, 22985 - 23000.

DOI : 10.1021/jacs.2c09830
A Theory-driven Synthesis of Symmetric and Unsymmetric 1,2-Bis(diphenylphosphino)ethane Analogues via Radical Difunctionalization of Ethylene

Takano, H.; Katsuyama, H.; Hayashi, H.; Kanna, W.; Harabuchi, Y.; Maeda, S.; Mita, T. Nat. Commun. 2022, 13, 7034.

DOI : 10.1038/s41467-022-34546-5
In Silico Reaction Screening with Difluorocarbene for N-Difluoroalkylative Dearomatization of Pyridines

Hayashi, H.; Katsuyama, H.; Takano, H.; Harabuchi, Y.; Maeda, S.; Mita, T. Nat. Synth. 2022, 1, 804 - 814.

DOI : 10.1038/s44160-022-00128-y
Iridium(III)-Catalyzed Asymmetric Site-Selective Carbene C–H Insertion during Late-Stage Transformation

Yamakawa, Y.; Ikuta, T.; Hayashi, H.; Hashimoto, K.; Fujii, R.; Kawashima, K.; Mori, S.; Uchida, T.; Katsuki, T. J. Org. Chem. 2022, 87, 6769 - 6780.

DOI : 10.1021/acs.joc.2c00470
Electrochemical Dearomative Dicarboxylation of Heterocycles with Highly Negative Reduction Potentials

You, Y.; Kanna, W.; Takano, H.; Hayashi, H.; Maeda, S.; Mita, T. J. Am. Chem. Soc. 2022, 144, 3685 - 3695.

DOI : 10.1021/jacs.1c13032
Radical Difunctionalization of Gaseous Ethylene Guided by Quantum Chemical Calculations: Selective Incorporation of Two Molecules of Ethylene

Takano, H.; You, Y.; Hayashi, H.; Harabuchi, Y.; Maeda, S.; ACS OmegaMita, T. ACS Omega 2021, 6, 33846 - 33854.

DOI : 10.1021/acsomega.1c05102
Carboxylation of a Palladacycle Formed via C(sp³)-H Activation: Theory-Driven Reaction Design

Kanna, W.; Harabuchi, Y.; Takano, H.; Hayashi, H.; Maeda, S.; Mita, T. Chem. Asian J. 2021, 16, 4072 - 4080.

DOI : 10.1002/asia.202100989
Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO₂: Computational Design, Scope, and Application

Hayashi, H.; Takano, H.; Katsuyama, H.; Harabuchi, Y.; Maeda, S.; Mita, T. Chem. Eur. J. 2021, 27, 10040 - 10047.

DOI : 10.1002/chem.202100812
Ruthenium-Catalyzed Asymmetric N-Acyl Nitrene Transfer Reaction: Imidation of Sulfide

Yoshitake, M; Hayashi, H.; Uchida, T. Org. Lett. 2020, 22, 4021 - 4025.

DOI : 10.1021/acs.orglett.0c01373
Non-Heme-Type Ruthenium Catalyzed Chemo- and Site-Selective C–H Oxidation

Doiuchi, D.; Nakamura, T.; Hayashi, H.; Uchida, T. Chem. Asian J. 2021, 15, 762 - 765.

DOI : 10.1002/asia.202000134
Iron-Catalyzed Asymmetric Inter- and Intramolecular Aerobic Oxidative Dearomatizing Spirocyclization of 2-Naphthols

Oguma, T.; Doiuchi, D.; Fujitomo, C.; Kim, C.; Hayashi, H.; Uchida, T.; Katsuki, T. Asian J. Org. Chem. 2020, 9, 404 - 404-415.

DOI : 10.1002/ajoc.201900602
Nitrene Transfer Reactions for Asymmetric C-H Amination: Recent Development

Hayashi, H.; Uchida, T. Eur. J. Org. Chem. 2020, 8, 909 - 916.

DOI : 10.1002/ejoc.201901562
Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols

Hayashi, H.; Ueno, T.; Kim, C.; Uchida, T. Org. Lett. 2020, 22, 1469 - 1474.

DOI : 10.1021/acs.orglett.0c00048
Chemoselective, Enzymatic C–H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor

Dydio, P.; Key, H. M.; Hayashi, H.; Clark, D. S.; Hartwig, J. F. J. Am. Chem. Soc. 2017, 139, 1750 - 1753.

DOI : 10.1021/jacs.6b11410
Chiral Ammonium Hypoiodite Salt-catalyzed Enantioselective Oxidative Cycloetherification to 2-Acyl Tetrahydrofurans

Uyanik, M.; Hayashi, H.; Iwata, H.; Ishihara, K. Chem. Lett. 2015, 45, 353 - 355.

DOI : 10.1246/cl.160004
High-Turnover Hypoiodite Catalysis for Asymmetric Synthesis of Tocopherols

Uyanik, M.; Hayashi, H.; Ishihara, K. Science 2014, 345, 291 - 294.

DOI : 10.1126/science.1254976

Contactお問い合わせ

美多剛　教授

Tsuyoshi Mita

E-mail： tmitaicredd.hokudai.ac.jp

HOKKAIDO UNIVERSITY Mita Group

Membersメンバー

林裕樹

Trans-Selective Carboxylative Cyclization of 1,6-Dienes Using the CO₂ Radical Anion

Strain-Releasing Ring-Opening Diphosphinations for the Synthesis of Diphosphine Ligands with Cyclic Backbones

γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO₂ Radical Anion

Revisiting the Electrochemical Carboxylation of Naphthalene with CO₂: Selective Monocarboxylation of 2-Substituted Naphthalenes

Quantum Chemical Calculations for Reaction Prediction in the Development of Synthetic Methodologies

Synthesis of Bicyclo[1.1.1]pentane (BCP)-Based Straight-Shaped Diphosphine Ligands

Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO₂ Radical Anion to (Hetero)Aromatics

Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction

Toward ab initio Reaction Discovery Using the Artificial Force Induced Reaction Method

Prediction of High-Yielding Single-Step or Cascade Pericyclic Reactions for the Synthesis of Complex Synthetic Targets

A Theory-driven Synthesis of Symmetric and Unsymmetric 1,2-Bis(diphenylphosphino)ethane Analogues via Radical Difunctionalization of Ethylene

In Silico Reaction Screening with Difluorocarbene for N-Difluoroalkylative Dearomatization of Pyridines

Iridium(III)-Catalyzed Asymmetric Site-Selective Carbene C–H Insertion during Late-Stage Transformation

Electrochemical Dearomative Dicarboxylation of Heterocycles with Highly Negative Reduction Potentials

Radical Difunctionalization of Gaseous Ethylene Guided by Quantum Chemical Calculations: Selective Incorporation of Two Molecules of Ethylene

Carboxylation of a Palladacycle Formed via C(sp³)-H Activation: Theory-Driven Reaction Design

Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO₂: Computational Design, Scope, and Application

Ruthenium-Catalyzed Asymmetric N-Acyl Nitrene Transfer Reaction: Imidation of Sulfide

Non-Heme-Type Ruthenium Catalyzed Chemo- and Site-Selective C–H Oxidation

Iron-Catalyzed Asymmetric Inter- and Intramolecular Aerobic Oxidative Dearomatizing Spirocyclization of 2-Naphthols

Nitrene Transfer Reactions for Asymmetric C-H Amination: Recent Development

Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols

Chemoselective, Enzymatic C–H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor

Chiral Ammonium Hypoiodite Salt-catalyzed Enantioselective Oxidative Cycloetherification to 2-Acyl Tetrahydrofurans

High-Turnover Hypoiodite Catalysis for Asymmetric Synthesis of Tocopherols

Contactお問い合わせ

美多剛　教授

Membersメンバー

林 裕樹

Trans-Selective Carboxylative Cyclization of 1,6-Dienes Using the CO2 Radical Anion

Strain-Releasing Ring-Opening Diphosphinations for the Synthesis of Diphosphine Ligands with Cyclic Backbones

γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO2 Radical Anion

Revisiting the Electrochemical Carboxylation of Naphthalene with CO2: Selective Monocarboxylation of 2-Substituted Naphthalenes

Quantum Chemical Calculations for Reaction Prediction in the Development of Synthetic Methodologies

Synthesis of Bicyclo[1.1.1]pentane (BCP)-Based Straight-Shaped Diphosphine Ligands

Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO2 Radical Anion to (Hetero)Aromatics

Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction

Toward ab initio Reaction Discovery Using the Artificial Force Induced Reaction Method

Prediction of High-Yielding Single-Step or Cascade Pericyclic Reactions for the Synthesis of Complex Synthetic Targets

A Theory-driven Synthesis of Symmetric and Unsymmetric 1,2-Bis(diphenylphosphino)ethane Analogues via Radical Difunctionalization of Ethylene

In Silico Reaction Screening with Difluorocarbene for N-Difluoroalkylative Dearomatization of Pyridines

Iridium(III)-Catalyzed Asymmetric Site-Selective Carbene C–H Insertion during Late-Stage Transformation

Electrochemical Dearomative Dicarboxylation of Heterocycles with Highly Negative Reduction Potentials

Radical Difunctionalization of Gaseous Ethylene Guided by Quantum Chemical Calculations: Selective Incorporation of Two Molecules of Ethylene

Carboxylation of a Palladacycle Formed via C(sp3)-H Activation: Theory-Driven Reaction Design

Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO2: Computational Design, Scope, and Application

Ruthenium-Catalyzed Asymmetric N-Acyl Nitrene Transfer Reaction: Imidation of Sulfide

Non-Heme-Type Ruthenium Catalyzed Chemo- and Site-Selective C–H Oxidation

Iron-Catalyzed Asymmetric Inter- and Intramolecular Aerobic Oxidative Dearomatizing Spirocyclization of 2-Naphthols

Nitrene Transfer Reactions for Asymmetric C-H Amination: Recent Development

Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols

Chemoselective, Enzymatic C–H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor

Chiral Ammonium Hypoiodite Salt-catalyzed Enantioselective Oxidative Cycloetherification to 2-Acyl Tetrahydrofurans

High-Turnover Hypoiodite Catalysis for Asymmetric Synthesis of Tocopherols

Contactお問い合わせ

美多 剛 教授

林裕樹

Trans-Selective Carboxylative Cyclization of 1,6-Dienes Using the CO₂ Radical Anion

γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO₂ Radical Anion

Revisiting the Electrochemical Carboxylation of Naphthalene with CO₂: Selective Monocarboxylation of 2-Substituted Naphthalenes

Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO₂ Radical Anion to (Hetero)Aromatics

Carboxylation of a Palladacycle Formed via C(sp³)-H Activation: Theory-Driven Reaction Design

Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO₂: Computational Design, Scope, and Application

美多剛　教授