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美多 剛

Tsuyoshi Mita

教授
TEL
011-706-9653
FAX
011-706-9655
E-mail
tmita@icredd.hokudai.ac.jp
ROOM
創成科学研究棟05-116

  1. Annulation Producing Diverse Heterocycles Promoted by Cobalt Hydride

    Sugimura, T. ; Yamada, R.; Kanna, W.; Mita, T.; Maeda, S. ; Szarłan, B.; Shigehisa, H.* ACS Catal. 2024, 14, 15514 - 15520.

    DOI : 10.1021/acscatal.4c05195

  2. Strain-Releasing Ring-Opening Diphosphinations for the Synthesis of Diphosphine Ligands with Cyclic Backbones

    Krishnan, C. G.; Takano, H.; Katsuyama, H.; Kanna, W.; Hayashi, H.; Mita, T.* JACS Au 2024, 4, 3777 - 3787.

    DOI : 10.1021/jacsau.4c00347

  3. Trans-Selective Carboxylative Cyclization of 1,6-Dienes Using the CO2 Radical Anion

    Song, Y.; Hayashi, H.*; Mangaonkar, S.; Mita, T.* Chem. Lett. 2024, 53, upae149.

    DOI : 10.1093/chemle/upae149

  4. Synthesis of Alkanoic Acids Using Carbon Dioxide through Catalytic C-C Bond Forming Reactions

    Rawat, V. K.; Mita, T.* Science of Synthesis 2024, 3, 291 - 314.

    DOI : 10.1055/sos-SD-120-00326

  5. γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO2 Radical Anion

    Mangaonkar, S. R.; Hayashi, H.; Kanna, W.; Debbarma, S.; Harabuchi, Y.; Maeda, S.*; Mita, T.* Precis. Chem. 2024, 2, 88 - 95.

    DOI : 10.1021/prechem.3c00117

     

  6. Quantum Chemical Calculations for Reaction Prediction in the Development of Synthetic Methodologies

    Hayashi, H.*; Maeda, S.; Mita, T.* Chem. Sci. 2023, 14, 11601 - 11616.

    DOI : 10.1039/D3SC03319H

  7. Revisiting the Electrochemical Carboxylation of Naphthalene with CO2: Selective Monocarboxylation of 2-Substituted Naphthalenes

    Rawat, V. K.; Hayashi, H.; Katsuyama, H.; Mangaonkar, S. R.; Mita, T.* Org. Lett. 2023, 25, 4231 - 4235.

    DOI : 10.1021/acs.orglett.3c01033

  8. Synthesis of Bicyclo[1.1.1]pentane (BCP)-Based Straight-Shaped Diphosphine Ligands

    Takano, H.; Katsuyama, H.; Hayashi, H.; Harukawa, M.; Tsurui, M.; Shoji, S.; Hasegawa, Y.; Maeda, S.; Mita, T.* Angew. Chem., Int. Ed. 2023, 62, e202303435.

    DOI : 10.1002/anie.202303435

  9. Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO2 Radical Anion to (Hetero)Aromatics

    Mangaonkar, S. R.; Hayashi, H.; Takano, H.; Kanna, W.; Maeda, S.; Mita, T.* ACS Catal. 2023, 13, 2482 - 2488.

    DOI : 10.1021/acscatal.2c06192

  10. Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction

    Harabuchi, Y.*; Hayashi, H.; Takano, H.; Mita, T.; Maeda, S.* Angew. Chem., Int. Ed. 2023, 62, e202211936.

    DOI : 10.1002/anie.202211936

  11. Toward ab initio Reaction Discovery Using the Artificial Force Induced Reaction Method

    Maeda, S.*; Harabuchi, Y.; Hayashi, H.; Mita, T.* Annu. Rev. Phys. Chem. 2023, 74, 13.1 - 13.25.

    DOI : 10.1146/annurev-physchem-102822-101025

  12. Prediction of High-Yielding Single-Step or Cascade Pericyclic Reactions for the Synthesis of Complex Synthetic Targets

    Mita, T.*; Takano, H.; Hayashi, H.; Kanna, W.; Harabuchi, Y.; Houk, K. N.; Maeda, S.* J. Am. Chem. Soc. 2022, 144, 22985 - 23000.

    DOI : 10.1021/jacs.2c09830

  13. A Theory-driven Synthesis of Symmetric and Unsymmetric 1,2-Bis(diphenylphosphino)ethane Analogues via Radical Difunctionalization of Ethylene

    Takano, H.; Katsuyama, H.; Hayashi, H.; Kanna, W.; Harabuchi, Y.; Maeda, S.*; Mita, T.* Nat. Commun. 2022, 13, 7034.

    DOI : 10.1038/s41467-022-34546-5

  14. In Silico Reaction Screening with Difluorocarbene for N-Difluoroalkylative Dearomatization of Pyridines

    Hayashi, H.; Katsuyama, H.; Takano, H.; Harabuchi, Y.; Maeda, S.*; Mita, T.* Nat. Synth. 2022, 1, 804 - 814.

    DOI : 10.1038/s44160-022-00128-y

  15. π-アリルパラジウムの極性転換による二酸化炭素を用いた触媒的カルボキシル化の開発

    美多 剛*; 樋口 裕紀; 佐藤 美洋* 有機合成化学協会誌 2022, 80 (9) , 806 - 816.

    DOI : 10.5059/yukigoseikyokaishi.80.806

  16. Electrochemical Dearomative Dicarboxylation of Heterocycles with Highly Negative Reduction Potentials

    You, Y.; Kanna, W.; Takano, H.; Hayashi, H.; Maeda, S.*; Mita, T.* J. Am. Chem. Soc. 2022, 144, 3685 - 3695.

    DOI : 10.1021/jacs.1c13032

  17. Recent Advances in the Catalytic Umpolung Carboxylation of Allylic Alcohol Derivatives with Carbon Dioxide

    You, Y.; Mita. T.* Asian J. Org. Chem. 2022, 11, e202200082.

    DOI : 10.1002/ajoc.202200082

  18. 末端アルケンを求核剤とするカルボニル化合物の触媒的アリル化反応

    道上 健一; 美多 剛*; 佐藤 美洋* 有機合成化学協会誌 2022, 80 (3) , 210 - 221.

    DOI : 10.5059/yukigoseikyokaishi.80.210

  19. Reactivity Prediction through Quantum Chemical Calculations

    Maeda, S.*; Harabuchi, Y.; Hasegawa, T.; Suzuki, K.; Mita, T. AsiaChem Magazine 2021, 2, 56 - 63.

    DOI : 10.51167/acm00024

  20. Radical Difunctionalization of Gaseous Ethylene Guided by Quantum Chemical Calculations: Selective Incorporation of Two Molecules of Ethylene

    Takano, H.; You, Y.; Hayashi, H.; Harabuchi, Y.; Maeda, S.*; Mita, T.* ACS Omega 2021, 6, 33846 - 33854.

    DOI : 10.1021/acsomega.1c05102

  21. Carboxylation of a Palladacycle Formed via C(sp3)-H Activation: Theory-Driven Reaction Design

    Kanna, W.; Harabuchi, Y.; Takano, H.; Hayashi, H.; Maeda, S.*; Mita, T.* Chem. Asian J. 2021, 16, 4072 - 4080.

    DOI : 10.1002/asia.202100989

  22. Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO2: Computational Design, Scope, and Application

    Hayashi, H.; Takano, H.; Katsuyama, H.; Harabuchi, Y.; Maeda, S.*; Mita, T.* Chem. Eur. J. 2021, 27, 10040 - 10047.

    DOI : 10.1002/chem.202100812

  23. Chemoselective Cleavage of Si-C(sp3) Bonds in Unactivated Tetraalkylsilanes Using Iodine Tris(trifluoroacetate)

    Matsuoka, K.; Komami, N.; Kojima, M.; Mita, T.; Suzuki, K.; Maeda, S.; Yoshino, T.*; Matsunaga, S.* J. Am. Chem. Soc. 2021, 143, 103 - 108.

    DOI : 10.1021/jacs.0c11645

  24. Discovery of a Synthesis Method for a Difluoroglycine Derivative Based on a Path Generated by Quantum Chemical Calculations

    Mita, T.*; Harabuchi, Y.; Maeda, S.* Chem. Sci. 2020, 11, 7569 - 7577.

    DOI : 10.1039/D0SC02089C

  25. General Synthesis of Trialkyl- and Dialkylarylsilylboranes: Versatile Silicon Nucleophiles in Organic Synthesis

    Shishido, R.; Uesugi, M.; Takahashi, R.; Mita, T.; Ishiyama, T.; Kubota, K.*; Ito, H.* J. Am. Chem. Soc. 2020, 142, 14125 - 14133.

    DOI : 10.1021/jacs.0c03011

  26. Catalytic Intramolecular Coupling of Ketoalkenes by Allylic C(sp3)-H Bond Cleavage: Synthesis of Five- and Six-Membered Carbocyclic Compounds

    Mita, T.*; Uchiyama, M.; Sato, Y.* Adv. Synth. Catal. 2020, 362, 1275 - 1280.

    DOI : 10.1002/adsc.201901533

  27. Syntheses of α-Amino Acids by Using CO2 as a C1 Source

    Mita, T.*; Sato, Y.* Chem. Asian J. 2019, 14, 2038 - 2047.

    DOI : 10.1002/asia.201900379

  28. Catalytic Carboxylation of Heteroaromatic Compounds: Double and Single Carboxylation with CO2

    Mita, T.*; Masutani, H.; Ishii, S.; Sato, Y.* Synlett 2019, 30, 841 - 844.

    DOI : 10.1055/s-0037-1612414

  29. Pd-Catalyzed Dearomative Carboxylation of Indolylmethanol Derivatives

    Mita, T.*; Ishii, S.; Higuchi, Y.; Sato, Y.* Org. Lett. 2018, 20, 7603 - 7606.

    DOI : 10.1021/acs.orglett.8b03337

  30. Cobalt-Catalyzed Nucleophilic Addition of the Allylic C(sp3)-H Bond of Simple Alkenes to Ketones

    Mita, T.*; Uchiyama, M.; Michigami, K.; Sato, Y.* Beilstein J. Org. Chem. 2018, 14, 2012 - 2017.

    DOI : 10.3762/bjoc.14.176

  31. Co-Catalyzed Direct Addition of Allylic C(sp3)-H Bonds to Ketones

    Mita, T.*; Hanagata, S.; Michigami, K.; Sato, Y.* Org. Lett. 2017, 19, 5876 - 5879.

    DOI : 10.1021/acs.orglett.7b02871

    • highlighted by Synfacts 2018, 14, 74.

  32. Cobalt-Catalyzed Allylic C(sp3)-H Carboxylation with CO2

    Michigami, K.; Mita, T.*; Sato, Y.* J. Am. Chem. Soc. 2017, 139, 6094 - 6097.

    DOI : 10.1021/jacs.7b02775

  33. Palladium-Catalyzed Intramolecular Arylative Carboxylation of Allenes with CO2 for the Construction of 3‑Substituted Indole-2-Carboxylic Acids

    Higuchi, Y.; Mita, T.*; Sato, Y.* Org. Lett. 2017, 19, 2710 - 2713.

    DOI : 10.1021/acs.orglett.7b01055

  34. One-Pot Synthesis of α-Amino Acids through Carboxylation of Ammonium Ylides with CO2 Followed by Alkyl Migration

    Mita, T.*; Sugawara, M.; Sato, Y.* J. Org. Chem. 2016, 81, 5236 - 5243.

    DOI : 10.1021/acs.joc.6b00837

  35. Palladium-Catalyzed Carboxylation of Activated Vinylcyclopropanes with CO2

    Mita, T.*; Tanaka, H.; Higuchi, Y.; Sato, Y.* Org. Lett. 2016 , 18, 2754 - 2757.

    DOI : 10.1021/acs.orglett.6b01231

  36. Stereoretentive Addition of N–tert-Butylsulfonyl-α-Amido Silanes to Aldehydes, Ketones, α,β-Unsaturated Esters, and Imines

    Mita, T.*; Saito, K.; Sugawara, M.; Sato, Y.* Chem. Asian. J. 2016, 11, 1528 - 1531.

    DOI : 10.1002/asia.201600270

  37. Highly Regioselective Palladium-Catalyzed Carboxylation of Allylic Alcohols with CO2

    Mita, T.*; Higuchi, Y.; Sato, Y.* Chem. Eur. J. 2015, 21, 16391 - 16394.

    DOI : 10.1002/chem.201503359

  38. A Strained Disilane-Promoted Carboxylation of Organic Halides with CO2 under Transition-Metal-Free Conditions

    Mita, T.*; Suga, K.; Sato, K.; Sato, Y.* Org. Lett. 2015, 17, 5276 - 5279.

    DOI : 10.1021/acs.orglett.5b02645

  39. C(sp3)-H結合のシリル化およびトリホウ素化、続く二酸化炭素によるカルボキシル化の開発

    美多 剛* 有機合成化学協会誌 2015, 73 (8) , 810 - 820.

    DOI : 10.5059/yukigoseikyokaishi.73.810

  40. Catalytic Enantioselective Silylation of N-Sulfonylimines: Asymmetric Synthesis of α-Amino Acids from CO2 via Stereospecific Carboxylation of α-Amino Silanes

    Mita, T.*; Sugawara, M.; Saito, K.; Sato, Y.* Org. Lett. 2014, 16, 3028 - 3031.

    DOI : 10.1021/ol501143c

    • highlighted by Synfacts 2014, 10, 839.

  41. Ruthenium-Catalyzed C-H Silylation of 1-Arylpyrazole Derivatives and Fluoride-Mediated Carboxylation: Use of Two Nitrogen Atoms of the Pyrazole Group

    Mita, T.*; Tanaka, H.; Michigami, K.; Sato, Y.* Synlett 2014, 25, 1291 - 1294.

    DOI : 10.1055/s-0033-1341230

  42. Synthesis of Arylglycines from CO2 through α-Amino Organomanganese Species

    Mita, T.*; Chen, J.; Sato, Y.* Org. Lett. 2014, 16, 2200 - 2203.

    DOI : 10.1021/ol500701n

    • highlighted by Synfacts 2014, 10, 742.

  43. Carboxylation with CO2 via Brook Rearrangement: Preparation of α-Hydroxy Acid Derivatives

    Mita, T.*; Higuchi, Y.; Sato, Y.* Org. Lett. 2014, 16, 14 - 17.

    DOI : 10.1021/ol403099f

  44. Iridium- and Rhodium-Catalyzed Dehydrogenative Silylations of C(sp3)-H Bonds Adjacent to a Nitrogen Atom Using Hydrosilanes

    Mita, T.*; Michigami, K.; Sato, Y.* Chem. Asian. J. 2013, 8, 2970 - 2973.

    DOI : 10.1002/asia.201300930

  45. One-Pot Synthesis of α-Amino Acids from CO2 Using Bismetal Reagents

    Mita, T.; Sato, Y.* J. Synth. Org. Chem., Jpn. 2013, 71 (11) , 1163 - 1171.

    DOI : 10.5059/yukigoseikyokaishi.71.1163

  46. Iridium-Catalyzed Triple C(sp3)-H Borylations: Construction of Triborylated sp3-Carbon Centers

    Mita, T.*; Ikeda, Y.; Michigami, K.; Sato, Y.* Chem. Commun. 2013, 49, 5601 - 5603.

    DOI : 10.1039/c3cc42675k

  47. One-Step Synthesis of Racemic α-Amino Acids from Aldehydes, Amine Components, and Gaseous CO2 by the Aid of a Bismetal Reagent

    Mita, T.*; Higuchi, Y.; Sato, Y.* Chem. Eur. J. 2013, 19, 1123 - 1128.

    DOI : 10.1002/chem.201202332

  48. One-Pot Synthesis of α-Amino Acids from CO2 Using a Bismetal Reagent with Si-B Bond

    Mita, T.*; Chen, J.; Sugawara, M.; Sato, Y.* Org. Lett. 2012, 14, 6202 - 6205.

    DOI : 10.1021/ol302952r

  49. Sequential Protocol for C(sp3)-H Carboxylation with CO2: Transition Metal-Catalyzed Benzylic C-H Silylation and Fluoride-Mediated Carboxylation

    Mita, T.*; Michigami, K.; Sato, Y.* Org. Lett. 2012, 14, 3462 - 3465.

    DOI : 10.1021/ol301431d

    • highlighted by Synfacts 2012, 8, 1132.

  50. Synthesis of Arylglycine and Mandelic Acid Derivatives through Carboxylations of α-Amido and α-Acetoxy Stannanes with Carbon Dioxide

    Mita, T.*; Sugawara, M.; Hasegawa, H.; Sato, Y.* J. Org. Chem. 2012, 77, 2159 - 2168.

    DOI : 10.1021/jo202597p

  51. Convenient and Practical Synthesis of α-Amido Stannanes

    Mita, T.*; Higuchi, Y.; Sato, Y.* Synthesis 2012, 44, 194 - 200.

    DOI : 10.1055/s-0031-1289597

    • PSP (Practical Synthetic Procedures)-article

  52. Practical Synthesis of N-Boc- and N-Cbz-α-Amido Stannanes from α-Amido Sulfones Using TMSSnBu3 and CsF

    Mita, T.*; Higuchi, Y.; Sato, Y.* Org. Lett. 2011, 13, 2354 - 2357.

    DOI : 10.1021/ol200599d

    • highlighted by Synfacts 2011, 7, 772.

  53. One-Pot Synthesis of α-Amino Acids from Imines through CO2 Incorporation: An Alternative Method for Strecker Synthesis

    Mita, T.*; Chen, J.; Sugawara, M.; Sato, Y.* Angew. Chem., Int. Ed. 2011, 50, 1393 - 1396.

    DOI : 10.1002/anie.201006422

  54. Bifunctional Asymmetric Catalysis with Hydrogen Chloride: Enantioselective Ring-Opening of Aziridines Catalyzed by a Phosphinothiourea

    Mita, T.; Jacobsen, E. N.* Synlett 2009, 2009, 1680 - 1684.

    DOI : 10.1055/s-0029-1217344

  55. Toward a Rational Design of the Assembly Structure of Polymetallic Asymmetric Catalysts: Design, Synthesis, and Evaluation of New Chiral Ligands for Catalytic Asymmetric Cyanation Reactions

    Fujimori, I.; Mita, T.; Maki, K.; Shiro, M.; Sato, A.; Furusho, S.; Kanai, M.*; Shibasaki, M.* Tetrahedron 2007, 63, 5820 - 5831.

    DOI : 10.1016/j.tet.2007.02.081

  56. Second Generation Catalytic Asymmetric Synthesis of Tamiflu: Allylic Substitution Route

    Mita, T.; Fukuda, N.; Roca, F. X.; Kanai, M.*; Shibasaki, M.* Org. Lett. 2007, 9, 259 - 262.

    DOI : 10.1021/ol062663c

    • highlighted by Synfacts 2007, 3, 567.

  57. Key Role of the Lewis Base Position in Asymmetric Bifunctional Catalysis: Design and Evaluation of a New Ligand for Chiral Polymetallic Catalysts

    Fujimori, I.; Mita, T.; Maki, K.; Shiro, M.; Sato, A.; Furusho, S.; Kanai, M.*; Shibasaki, M.* J. Am. Chem. Soc. 2006, 128, 16438 - 16439.

    DOI : 10.1021/ja067003h

    • highlighted by Synfacts 2007, 3, 285.

  58. Assembly State of Catalytic Modules as Chiral Switches in Asymmetric Strecker Amino Acid Synthesis

    Kato, N.; Mita, T.; Kanai, M.*; Therrien, B.; Kawano, M.; Yamaguchi, K.; Danjo, H.; Sei, Y.; Sato, A.; Furusho, S.; Shibasaki, M.* J. Am. Chem. Soc. 2006, 128, 6768 - 6769.

    DOI : 10.1021/ja060841r

  59. De Novo Synthesis of Tamiflu via a Catalytic Enantioselective Ring-Opening of meso-Aziridines with TMSN3

    Fukuta, Y.; Mita, T.; Fukuda, N.; Kanai, M.*; Shibasaki, M.* J. Am. Chem. Soc. 2006, 128, 6312 - 6313.

    DOI : 10.1021/ja061696k

    • highlighted by Synfacts 2006, 2, 975.

  60. Catalytic Enantioselective Desymmetrization of meso–N-Acylaziridines with TMSCN

    Mita, T.; Fujimori, I.; Wada, R.; Wen, J.; Kanai, M.*; Shibasaki, M.* J. Am. Chem. Soc. 2005, 127, 11252 - 11253.

    DOI : 10.1021/ja053486y

    • highlighted by Synfacts 2005, 1, 322.

  61. 光学活性コバルト錯体をルイス酸として用いる触媒的不斉合成反応

    毛塚 智子; 美多 剛; 岩倉 いずみ; 池野 健人; 山田 徹* 有機合成化学協会誌 2005, 63 (6) , 604 - 615.

    DOI : 10.5059/yukigoseikyokaishi.63.604

  62. Catalytic Enantioselective Conjugate Addition of Cyanide to α,β-Unsaturated N-Acylpyrroles

    Mita, T.; Sasaki, K.; Kanai, M.*; Shibasaki, M.* J. Am. Chem. Soc. 2005, 127, 514 - 515.

    DOI : 10.1021/ja043424s

  63. Enantioselective 1,3-Dipolar Cycloaddition Reaction of Nitrones with α,β-Unsaturated Aldehydes Catalyzed by Cationic 3-Oxobutylideneaminatocobalt(III) Complexes

    Kezuka, S.; Ohtsuki, N.; Mita, T.; Kogami, Y.; Ashizawa, T.; Ikeno, T.; Yamada, T.* Bull. Chem. Soc. Jpn. 2003, 76, 2197 - 2207.

    DOI : 10.1246/bcsj.76.2197

  64. Enantioselective 1,3-Dipolar Cycloaddition Reactions between Nitrones and α-Substituted α,β-Unsaturated Aldehydes Catalyzed by Chiral Cationic Cobalt(III) Complexes

    Ohtsuki, N.; Kezuka, S.; Kogami, Y.; Mita, T; Ashizawa, T.; Ikeno, T.; Yamada, T.* Synthesis 2003, 2003, 1462 - 1466.

    DOI : 10.1055/s-2003-40194

  65. Enantioselective 1,3-Dipolar Cycloaddition of Nitrones Catalyzed by Optically Active Cationic Cobalt(III) Complexes

    Mita, T.; Ohtsuki, N.; Ikeno, T.; Yamada, T.* Org. Lett. 2002, 4, 2457 - 2460.

    DOI : 10.1021/ol026079p

  66. Highly Active 3-Oxobutylideneaminatocobalt Complex Catalysts for an Enantioselective Hetero Diels-Alder Reaction

    Kezuka, S.; Mita, T.; Ohtsuki, N.; Ikeno, T.; Yamada, T.* Bull. Chem. Soc. Jpn. 2001, 74, 1333 - 1342.

    DOI : 10.1246/bcsj.74.1333

  67. Optically Active Cationic Cobalt(III) Complexes: Highly Efficient Catalysts for Enantioselective Hetero Diels-Alder Reaction

    Kezuka, S.; Mita, T.; Ohtsuki, N.; Ikeno, T.; Yamada, T.* Chem. Lett. 2000, 29, 824 - 825.

    DOI : 10.1246/cl.2000.824

  68. Optically Active Aldiminato Cobalt(II) Complex Catalyst for Enantioselective Hetero Diels-Alder Reaction

    Yamada, T.*; Kezuka, S.; Mita, T.; Ikeno, T. Heterocycles 2000, 52, 1041 - 1045.

    DOI : 10.3987/COM-99-S126

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美多 剛　教授

Tsuyoshi Mita
E-mail： tmitaicredd.hokudai.ac.jp