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田中耕作三世

田中耕作三世

Kosaku Tanaka, III

特任助教

TEL: 011-706-9654
FAX: 011-706-9655
E-mail: k3tanaka@icredd.hokudai.ac.jp
ROOM: 創成科学研究棟05-116

Recent Advances in the Direct N–C(sp²) Nitrone Synthesis from Oxime

Tanaka, K., III* Eur. J. Org. Chem. 2024, e202400202.

DOI : 10.1002/ejoc.202400202
Ketyl Radical Generation by Photoexcited Palladium and Development of Organopalladium-Type Reactions

Tanaka, K., III* ACS Catal. 2024, 14, 5269 - 5274.

DOI : 10.1021/acscatal.4c00510
Gold(III)-catalyzed Propargylic Substitution Reaction Followed by Cycloisomerization for Synthesis of Poly-Substituted Furans from N-Tosylpropargyl Amines with 1,3-Dicarbonyl Compounds

Morita, N.*; Uchida, S.; Chiaki, H.; Ishii, N.; Tanikawa, K.; Tanaka, K., III; Hashimoto, Y.; Tamura, O.* Molecules 2024, 29, 378.

DOI : 10.3390/molecules29020378
(E)-5-[Bromo (phenyl) methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole

Morita, N.*; Kurami, S.; Ishii, N.; Tanaka, K., III; Hashimoto, Y.; Tamura, O.* Molbank 2024, 2024, M1769.

DOI : 10.3390/M1769
Intermolecular 1,3-Dipolar Cycloaddition Reaction of N-Carbamoyl Nitrones Generated by N-Selective Carbamoylation of Oximes with Isocyanates

Yamamoto, A.; Tanaka, K., III; Hashimoto, Y.*; Morita, N.; Tamura, O.* Chem. Eur. J. 2024, 30, e202303790.

DOI : 10.1002/chem.202303790
Direct Generation of N-Alkoxycarbonyl Nitrones from Oximes: Intramolecular Cycloaddition of Oximes Having Alkene Moieties

Sagara, H.; Suzuki, Y.; Morita, N.; Ban, S.; Tanaka, K., III; Yamamoto, A.; Hashimoto, Y.; Tamura, O.* Adv. Synth. Catal. 2023, 365, 3927 - 3934.

DOI : 10.1002/adsc.202300793
Electrophilic C3-H Alkenylation of 2,6-Dialkoxypyridine Derivatives via Pd(II)/Tl(III) Reaction System

Yamada, T.*; Tanaka, K., III; Hashimoto, Y.; Morita, N.; Tamura, O.* Adv. Synth. Catal. 2023, 365, 3138 - 3148.

DOI : 10.1002/adsc.202300650
Synthesis of N-Aryl Isoxazolidines by Photo-promoted N-Selective Arylation of Oximes and Cyclization Using Hypervalent Iodine Reagents and Copper Catalyst

Tanaka, K., III*; Yoshida, M.; Yamamoto, A.; Hashimoto, Y.; Morita, N.; Tamura, O.* Adv. Synth. Catal. 2023, 365, 1419 - 1424.

DOI : 10.1002/adsc.202300110
(Z)-5-Benzylidene-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole

Morita, N.*; Chiaki, H.; Aonuma, S.; Tanaka, K., III; Hashimoto, Y.; Tamura, O.* Molbank 2023, 2023, M1600.

DOI : 10.3390/m1600
Sustainable Chemical Synthesis of 2,3-Dihydrobenzofurans/1,2,3-Trisubstituted Indanes in Water Using a Permethylated β-Cyclodextrin-tagged NHC-Gold Catalyst

Morita, N.*; Chiaki, H.; Tanaka, K., III; Hashimoto, Y.; Tamura, O.; Krause, N.* Synlett 2023, 34, 1425 - 1432.

DOI : 10.1055/a-2016-6577
Gold-catalyzed Formal (3+2) Cycloaddition in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Poly-substituted Indanes from Benzyl Alcohols with 1-Phenylpropenes

Morita, N.*; Chiaki, H.; Ikeda, K.; Tanaka, K., III; Hashimoto, Y.; Tamura, O.* Synlett 2023, 34, 1068 - 1074.

DOI : 10.1055/a-2002-4122
Directing-group-free Palladium-catalyzed C-H Arylation of Aldoxime Using Oxime’s Umpolung Properties

Tanaka, K., III*; Hashimoto, Y.; Morita, N.; Tamura, O.* Org. Lett. 2022, 24, 8954 - 8958.

DOI : 10.1021/acs.orglett.2c03387
Cationic Palladium(II)-catalyzed Synthesis of Substituted Pyridines from α,β-Unsaturated Oxime Ethers

Yamada, T.; Hashimoto, Y.; Tanaka, K., III; Morita, N.; Tamura, O.* RSC Adv. 2022, 12, 21548 - 21557.

DOI : 10.1039/d2ra03875g
Highly Oxidized γ-Lactam-containing Natural Products: Total Synthesis and Biological Evaluation

Tanaka, K., III*; Kobayashi, K.*; Kogen, H. Heterocycles 2021, 7, 1235 - 1285.

DOI : 10.3987/REV-20-944
Enantioselective Total Synthesis of (+)-Rubrobramide, (+)-Talaramide A, and (−)-Berkeleyamide D by a Skeletal Diversification Strategy

Tanaka, K., III; Kobayashi, K.*; Kogen, H.* Chem. Commun. 2021, 57, 9780 - 9783.

DOI : 10.1039/D1CC04290D
Electrophilic Epoxidation of α,β-Unsaturated Oximes with Dioxiranes and Ring Opening of the Epoxides

Furugoori, M.; Yoshida, K.; Hashimoto, Y.; Morita, N.; Tanaka, K., III; Tamura, O.* Chem. Pharm. Bull. 2021, 69, 1010 - 1016.

DOI : 10.1248/cpb.c21-00533
Gold-catalyzed Formal [3+2]Cycloaddition of p-Quinones and 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Benzofuran Neolignans

Morita, N.*; Chiaki, H.; Araki, R.; Tanaka, K., III; Hashimoto Y.; Tamura, O.* Heterocycles 2021, 103, 714 - 722.

DOI : 10.3987/com-20-s(k)71
Palladium(II)-catalyzed Substituted Pyridine Synthesis from α,β-Unsaturated Oxime Ethers via a C-H Alkenylation/Aza 6π-Electrocyclization Approach

Yamada, T.; Hashimoto, Y.; Tanaka, K., III; Morita, N.; Tamura, O.* Org. Lett. 2021, 23, 1659 - 1663.

DOI : 10.1021/acs.orglett.1c00061
Thioether Ligand-enabled Cationic Palladium(II)-catalyzed Electrophilic C-H Arylation of α,β-Unsaturated Oxime Ethers

Yamada, T.; Hashimoto, Y.; Tanaka, K., III; Morita, N.; Tamura, O.* J. Org. Chem. 2020, 85, 12315 - 12328.

DOI : 10.1021/acs.joc.0c01570
Synthesis and Formation Mechanism of a Compound with an Unprecedented Skeleton: Dodecahydro-4,10:5,9-diepoxydipyrrolo[3,4-b:3′,4′-f][1,5]diazocine

Shinoda, M.; Morita, N.; Tanaka, K., III; Hashimoto, Y.; Ban, S.; Tamura, O.* Chem. Pharm. Bull. 2020, 21, 4245 - 4249.

DOI : 10.1248/cpb.c20-00561
O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-selective Reagents for Alkoxy Carbonylation of Amino Groups

Suzuki, T.; Tanaka, K., III; Hashimoto, Y.; Morita, N.; Tamura, O.* Synlett 2020, 31, 899 - 902.

DOI : 10.1055/s-0039-1690856
Intramolecular Activation of Imidate with Cationic Gold(I) Catalyst: a New Benzylation Reaction of Alcohols

Ban, S.; Endo, T.; Matsui, R.; Morita, N.; Hashimoto, Y.; Tanaka, K., III; Tamura, O.* Tetrahedron lett. 2020, 30, 152233 - 152235.

DOI : 10.1016/j.tetlet.2020.152233
(−)-L-755,807の全合成およびアミロイドβ凝集阻害活性

田中耕作三世; 小林健一*; 古源寛* 有機合成化学協会誌 2019, 77 (7) , 673 - 683.

DOI : 10.5059/yukigoseikyokaishi.77.673
Chelation-based Homologation by Reaction of Organometallic Reagents with O-Alkyl S-Pyridin-2-yl Thiocarbonates: Synthesis of Esters from Grignard Reagents

Usami, S.; Suzki, S.; Mano, K.; Tanaka, K., III; Hashimoto, Y.; Morita, N.; Tamura, O.* Synlett 2019, 30, 1561 - 1564.

DOI : 10.1055/s-0037-1611868
Studies toward Identifying the Pharmacophore of L-755,807 for Amyloid-β Aggregation Inhibitory Activity

Kobayashi, K.*; Tanaka, K., III; Honma, Y.; Suzuki, M.; Kogen, H.* Heterocycles 2019, 98, 1796 - 1776.

DOI : 10.3987/COM-19-14193
Total synthesis, stereochemical assignment, and biological evaluation of L-755,807

Tanaka, K. III, ; Honma, Y.; Yamaguchi, C.; Aoki, L.; Saito, M.; Suzuki, M.; Arahata, K.; Kinoshita, K; Koyama, K.; Kobayashi, K.*; Kogen, H.* Tetrahedron 2019, 75, 1085 - 1097.

DOI : 10.1016/j.tet.2019.01.020
Stereospecific Ring-Expanding Skeletal Rearrangement of Isoindoline to Tetrahydroisoquinoline via a Sequential Aziridine Ring Formation/Opening

Kobayashi, K*; Endo, R.; Honma, Y.; Kasahara, H.; Saito, H.; Tanaka, K., III; Suzuki, M.; Kogen, H.* Heterocycles 2019, 99, 1239 - 1250.

DOI : 10.3987/COM-18-S(F)98
Recent Topics of the Natural Product Synthesis by Horner–Wadsworth–Emmons Reaction

Kobayashi, K.*; Tanaka, K., III; Kogen, H.* Tetrahedron Lett. 2018, 59, 568 - 582.

DOI : 10.1016/j.tetlet.2017.12.076
Total synthesis of lissoclinolide by acid-induced lactonization of an (E)-α-bromo-γ,δ-epoxy acrylate derivative

Kobayashi, K.*; Kuwahara, K.; Tanaka, K., III; Kunimura, R.; Kogen, H.* Heterocycles 2019, 99, 1019 - 1027.

DOI : 10.3987/COM-18-S(T)84
Total Synthesis and Biological Evaluation of Phaeosphaeride

Kobayashi, K.*; Tanaka, K., III; Kogen, H.* Catalysts 2018, 8, 206 - 215.

DOI : 10.3390/catal8050206
Total synthesis of (−)-phaeosphaeride B by a biomimetic conversion from (−)-phaeosphaeride A

Kobayashi, K.*; Kunimura, R.; Tanaka, K., III; Kogen, H.* Tetrahedron 2017, 73, 2382 - 2388.

DOI : 10.1016/j.tet.2017.03.020
Efficient Synthesis of syn-α-Alkoxy Epoxide via a Diastereoselective Darzens Reaction

Tanaka, K., III; Kobayashi, K.*; Kogen, H.* Tetrahedron 2017, 73, 2062 - 2067.

DOI : 10.1016/j.tet.2017.02.051
Total Synthesis of (−)-L-755,807: Establishment of Relative and Absolute Configurations

Tanaka, K., III; Kobayashi, K.*; Kogen, H.* Org. Lett. 2016, 18, 1920 - 1923.

DOI : 10.1021/acs.orglett.6b00758

Contactお問い合わせ

美多剛　教授

Tsuyoshi Mita

E-mail： tmita@icredd.hokudai.ac.jp

HOKKAIDO UNIVERSITY Mita Group

Membersメンバー

田中耕作三世

Recent Advances in the Direct N–C(sp²) Nitrone Synthesis from Oxime

Ketyl Radical Generation by Photoexcited Palladium and Development of Organopalladium-Type Reactions

Gold(III)-catalyzed Propargylic Substitution Reaction Followed by Cycloisomerization for Synthesis of Poly-Substituted Furans from N-Tosylpropargyl Amines with 1,3-Dicarbonyl Compounds

(E)-5-[Bromo (phenyl) methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole

Intermolecular 1,3-Dipolar Cycloaddition Reaction of N-Carbamoyl Nitrones Generated by N-Selective Carbamoylation of Oximes with Isocyanates

Direct Generation of N-Alkoxycarbonyl Nitrones from Oximes: Intramolecular Cycloaddition of Oximes Having Alkene Moieties

Electrophilic C3-H Alkenylation of 2,6-Dialkoxypyridine Derivatives via Pd(II)/Tl(III) Reaction System

Synthesis of N-Aryl Isoxazolidines by Photo-promoted N-Selective Arylation of Oximes and Cyclization Using Hypervalent Iodine Reagents and Copper Catalyst

(Z)-5-Benzylidene-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole

Sustainable Chemical Synthesis of 2,3-Dihydrobenzofurans/1,2,3-Trisubstituted Indanes in Water Using a Permethylated β-Cyclodextrin-tagged NHC-Gold Catalyst

Gold-catalyzed Formal (3+2) Cycloaddition in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Poly-substituted Indanes from Benzyl Alcohols with 1-Phenylpropenes

Directing-group-free Palladium-catalyzed C-H Arylation of Aldoxime Using Oxime’s Umpolung Properties

Cationic Palladium(II)-catalyzed Synthesis of Substituted Pyridines from α,β-Unsaturated Oxime Ethers

Highly Oxidized γ-Lactam-containing Natural Products: Total Synthesis and Biological Evaluation

Enantioselective Total Synthesis of (+)-Rubrobramide, (+)-Talaramide A, and (−)-Berkeleyamide D by a Skeletal Diversification Strategy

Electrophilic Epoxidation of α,β-Unsaturated Oximes with Dioxiranes and Ring Opening of the Epoxides

Gold-catalyzed Formal [3+2]Cycloaddition of p-Quinones and 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Benzofuran Neolignans

Palladium(II)-catalyzed Substituted Pyridine Synthesis from α,β-Unsaturated Oxime Ethers via a C-H Alkenylation/Aza 6π-Electrocyclization Approach

Thioether Ligand-enabled Cationic Palladium(II)-catalyzed Electrophilic C-H Arylation of α,β-Unsaturated Oxime Ethers

Synthesis and Formation Mechanism of a Compound with an Unprecedented Skeleton: Dodecahydro-4,10:5,9-diepoxydipyrrolo[3,4-b:3′,4′-f][1,5]diazocine

O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-selective Reagents for Alkoxy Carbonylation of Amino Groups

Intramolecular Activation of Imidate with Cationic Gold(I) Catalyst: a New Benzylation Reaction of Alcohols

(−)-L-755,807の全合成およびアミロイドβ凝集阻害活性

Chelation-based Homologation by Reaction of Organometallic Reagents with O-Alkyl S-Pyridin-2-yl Thiocarbonates: Synthesis of Esters from Grignard Reagents

Studies toward Identifying the Pharmacophore of L-755,807 for Amyloid-β Aggregation Inhibitory Activity

Total synthesis, stereochemical assignment, and biological evaluation of L-755,807

Stereospecific Ring-Expanding Skeletal Rearrangement of Isoindoline to Tetrahydroisoquinoline via a Sequential Aziridine Ring Formation/Opening

Recent Topics of the Natural Product Synthesis by Horner–Wadsworth–Emmons Reaction

Total synthesis of lissoclinolide by acid-induced lactonization of an (E)-α-bromo-γ,δ-epoxy acrylate derivative

Total Synthesis and Biological Evaluation of Phaeosphaeride

Total synthesis of (−)-phaeosphaeride B by a biomimetic conversion from (−)-phaeosphaeride A

Efficient Synthesis of syn-α-Alkoxy Epoxide via a Diastereoselective Darzens Reaction

Total Synthesis of (−)-L-755,807: Establishment of Relative and Absolute Configurations

Contactお問い合わせ

美多剛　教授

Membersメンバー

田中 耕作三世

Recent Advances in the Direct N–C(sp2) Nitrone Synthesis from Oxime

Ketyl Radical Generation by Photoexcited Palladium and Development of Organopalladium-Type Reactions

Gold(III)-catalyzed Propargylic Substitution Reaction Followed by Cycloisomerization for Synthesis of Poly-Substituted Furans from N-Tosylpropargyl Amines with 1,3-Dicarbonyl Compounds

(E)-5-[Bromo (phenyl) methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole

Intermolecular 1,3-Dipolar Cycloaddition Reaction of N-Carbamoyl Nitrones Generated by N-Selective Carbamoylation of Oximes with Isocyanates

Direct Generation of N-Alkoxycarbonyl Nitrones from Oximes: Intramolecular Cycloaddition of Oximes Having Alkene Moieties

Electrophilic C3-H Alkenylation of 2,6-Dialkoxypyridine Derivatives via Pd(II)/Tl(III) Reaction System

Synthesis of N-Aryl Isoxazolidines by Photo-promoted N-Selective Arylation of Oximes and Cyclization Using Hypervalent Iodine Reagents and Copper Catalyst

(Z)-5-Benzylidene-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole

Sustainable Chemical Synthesis of 2,3-Dihydrobenzofurans/1,2,3-Trisubstituted Indanes in Water Using a Permethylated β-Cyclodextrin-tagged NHC-Gold Catalyst

Gold-catalyzed Formal (3+2) Cycloaddition in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Poly-substituted Indanes from Benzyl Alcohols with 1-Phenylpropenes

Directing-group-free Palladium-catalyzed C-H Arylation of Aldoxime Using Oxime’s Umpolung Properties

Cationic Palladium(II)-catalyzed Synthesis of Substituted Pyridines from α,β-Unsaturated Oxime Ethers

Highly Oxidized γ-Lactam-containing Natural Products: Total Synthesis and Biological Evaluation

Enantioselective Total Synthesis of (+)-Rubrobramide, (+)-Talaramide A, and (−)-Berkeleyamide D by a Skeletal Diversification Strategy

Electrophilic Epoxidation of α,β-Unsaturated Oximes with Dioxiranes and Ring Opening of the Epoxides

Gold-catalyzed Formal [3+2]Cycloaddition of p-Quinones and 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Benzofuran Neolignans

Palladium(II)-catalyzed Substituted Pyridine Synthesis from α,β-Unsaturated Oxime Ethers via a C-H Alkenylation/Aza 6π-Electrocyclization Approach

Thioether Ligand-enabled Cationic Palladium(II)-catalyzed Electrophilic C-H Arylation of α,β-Unsaturated Oxime Ethers

Synthesis and Formation Mechanism of a Compound with an Unprecedented Skeleton: Dodecahydro-4,10:5,9-diepoxydipyrrolo[3,4-b:3′,4′-f][1,5]diazocine

O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-selective Reagents for Alkoxy Carbonylation of Amino Groups

Intramolecular Activation of Imidate with Cationic Gold(I) Catalyst: a New Benzylation Reaction of Alcohols

(−)-L-755,807の全合成およびアミロイドβ凝集阻害活性

Chelation-based Homologation by Reaction of Organometallic Reagents with O-Alkyl S-Pyridin-2-yl Thiocarbonates: Synthesis of Esters from Grignard Reagents

Studies toward Identifying the Pharmacophore of L-755,807 for Amyloid-β Aggregation Inhibitory Activity

Total synthesis, stereochemical assignment, and biological evaluation of L-755,807

Stereospecific Ring-Expanding Skeletal Rearrangement of Isoindoline to Tetrahydroisoquinoline via a Sequential Aziridine Ring Formation/Opening

Recent Topics of the Natural Product Synthesis by Horner–Wadsworth–Emmons Reaction

Total synthesis of lissoclinolide by acid-induced lactonization of an (E)-α-bromo-γ,δ-epoxy acrylate derivative

Total Synthesis and Biological Evaluation of Phaeosphaeride

Total synthesis of (−)-phaeosphaeride B by a biomimetic conversion from (−)-phaeosphaeride A

Efficient Synthesis of syn-α-Alkoxy Epoxide via a Diastereoselective Darzens Reaction

Total Synthesis of (−)-L-755,807: Establishment of Relative and Absolute Configurations

Contactお問い合わせ

美多 剛 教授

田中耕作三世

Recent Advances in the Direct N–C(sp²) Nitrone Synthesis from Oxime

美多剛　教授